The use of TLR2 modified BMSCs for enhanced bone regeneration in the inflammatory micro-environment.
Identifieur interne : 000054 ( Main/Exploration ); précédent : 000053; suivant : 000055The use of TLR2 modified BMSCs for enhanced bone regeneration in the inflammatory micro-environment.
Auteurs : Qin Zhou [République populaire de Chine] ; Xiaoyu Gu [République populaire de Chine] ; Jiachen Dong [République populaire de Chine] ; Chao Zhu [République populaire de Chine] ; Zhen Cai [République populaire de Chine] ; Dongmei He [République populaire de Chine] ; Chi Yang [République populaire de Chine] ; Ling Xu [République populaire de Chine] ; Jiawei Zheng [République populaire de Chine]Source :
- Artificial cells, nanomedicine, and biotechnology [ 2169-141X ] ; 2019.
Descripteurs français
- KwdFr :
- Alvéole dentaire (anatomopathologie), Alvéole dentaire (imagerie diagnostique), Alvéole dentaire (métabolisme), Alvéole dentaire (physiopathologie), Animaux (MeSH), Cellules souches mésenchymateuses (cytologie), Cellules souches mésenchymateuses (métabolisme), Chiens (MeSH), Différenciation cellulaire (MeSH), Inflammation (anatomopathologie), Inflammation (métabolisme), Inflammation (physiopathologie), Microenvironnement cellulaire (MeSH), Microtomographie aux rayons X (MeSH), Mâle (MeSH), Néovascularisation physiologique (MeSH), Ostéogenèse (MeSH), Récepteur de type Toll-2 (génétique), Récepteur de type Toll-2 (métabolisme), Régénération osseuse (MeSH), Transduction du signal (MeSH), Transplantation de cellules souches mésenchymateuses (MeSH).
- MESH :
- anatomopathologie : Alvéole dentaire, Inflammation.
- cytologie : Cellules souches mésenchymateuses.
- génétique : Récepteur de type Toll-2.
- imagerie diagnostique : Alvéole dentaire.
- métabolisme : Alvéole dentaire, Cellules souches mésenchymateuses, Inflammation, Récepteur de type Toll-2.
- physiopathologie : Alvéole dentaire, Inflammation.
- Animaux, Chiens, Différenciation cellulaire, Microenvironnement cellulaire, Microtomographie aux rayons X, Mâle, Néovascularisation physiologique, Ostéogenèse, Régénération osseuse, Transduction du signal, Transplantation de cellules souches mésenchymateuses.
English descriptors
- KwdEn :
- Animals (MeSH), Bone Regeneration (MeSH), Cell Differentiation (MeSH), Cellular Microenvironment (MeSH), Dogs (MeSH), Inflammation (metabolism), Inflammation (pathology), Inflammation (physiopathology), Male (MeSH), Mesenchymal Stem Cell Transplantation (MeSH), Mesenchymal Stem Cells (cytology), Mesenchymal Stem Cells (metabolism), Neovascularization, Physiologic (MeSH), Osteogenesis (MeSH), Signal Transduction (MeSH), Toll-Like Receptor 2 (genetics), Toll-Like Receptor 2 (metabolism), Tooth Socket (diagnostic imaging), Tooth Socket (metabolism), Tooth Socket (pathology), Tooth Socket (physiopathology), X-Ray Microtomography (MeSH).
- MESH :
- chemical , genetics : Toll-Like Receptor 2.
- cytology : Mesenchymal Stem Cells.
- diagnostic imaging : Tooth Socket.
- metabolism : Inflammation, Mesenchymal Stem Cells, Toll-Like Receptor 2, Tooth Socket.
- pathology : Inflammation, Tooth Socket.
- physiopathology : Inflammation, Tooth Socket.
- Animals, Bone Regeneration, Cell Differentiation, Cellular Microenvironment, Dogs, Male, Mesenchymal Stem Cell Transplantation, Neovascularization, Physiologic, Osteogenesis, Signal Transduction, X-Ray Microtomography.
Abstract
The repair of periodontal bone tissue defects in patients with periodontitis is one of the major challenges for dentists. Stem cell-based bone regeneration has been considered as a promising strategy to restore the lost periodontal bone tissue. However, the local inflammatory environment of periodontal tissue affects stem cell-based periodontal bone regeneration. Toll-like receptor 2 (TLR2), a member of the TLR family, plays an important role in regulating immunoreaction. Previous studies have shown that the activation of TLR2 signaling pathway is involved in enhancing tissue vascularization and wound healing. However, the mechanisms underlying the therapeutic effects of TLR2 on regulating bone marrow stromal cells (BMSCs) mediated periodontal bone tissue regeneration still need to be further investigated. In this study, we tested the effect of TLR2 on regulating BMSCs mediated alveolar bone regeneration by establishing a TLR2 gene-modified canine BMSCs using a lentivirus. Activation of TLR2 significantly enhanced the expression of hypoxia-inducible factor-1α (HIF-1α) and bone morphogenetic protein 2 (BMP-2) and then upregulated the expression of their downstream osteogenic and angiogenic related gene in BMSCs. TLR2-BMSCs mediated bone regeneration in canine tooth extraction sockets under an inflammatory environment demonstrated that activation of the TLR2 signaling pathway significantly stimulated BMSCs meditated angiogenesis and osteogenesis.
DOI: 10.1080/21691401.2019.1626867
PubMed: 31387403
Affiliations:
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Medicine , Shanghai , China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>a Department of Oral and Maxillofacial Surgery, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai </wicri:regionArea><wicri:noRegion>Shanghai </wicri:noRegion></affiliation></author><author><name sortKey="Xu, Ling" sort="Xu, Ling" uniqKey="Xu L" first="Ling" last="Xu">Ling Xu</name><affiliation wicri:level="1"><nlm:affiliation>b Department of Prothodontics, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai , China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>b Department of Prothodontics, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai </wicri:regionArea><wicri:noRegion>Shanghai </wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>e Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology , Shanghai , China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>e Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology , Shanghai </wicri:regionArea><wicri:noRegion>Shanghai </wicri:noRegion></affiliation></author><author><name sortKey="Zheng, Jiawei" sort="Zheng, Jiawei" uniqKey="Zheng J" first="Jiawei" last="Zheng">Jiawei Zheng</name><affiliation wicri:level="1"><nlm:affiliation>a Department of Oral and Maxillofacial Surgery, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai , China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>a Department of Oral and Maxillofacial Surgery, Ninth People's Hospital Affiliated to Shanghai Jiao 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wicri:level="1"><nlm:affiliation>a Department of Oral and Maxillofacial Surgery, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai , China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>a Department of Oral and Maxillofacial Surgery, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai </wicri:regionArea><wicri:noRegion>Shanghai </wicri:noRegion></affiliation></author><author><name sortKey="Gu, Xiaoyu" sort="Gu, Xiaoyu" uniqKey="Gu X" first="Xiaoyu" last="Gu">Xiaoyu Gu</name><affiliation wicri:level="1"><nlm:affiliation>b Department of Prothodontics, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai , China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>b Department of Prothodontics, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai </wicri:regionArea><wicri:noRegion>Shanghai </wicri:noRegion></affiliation></author><author><name sortKey="Dong, Jiachen" sort="Dong, Jiachen" uniqKey="Dong J" first="Jiachen" last="Dong">Jiachen Dong</name><affiliation wicri:level="1"><nlm:affiliation>c Department of Periodontology, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai , China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>c Department of Periodontology, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai </wicri:regionArea><wicri:noRegion>Shanghai </wicri:noRegion></affiliation></author><author><name sortKey="Zhu, Chao" sort="Zhu, Chao" uniqKey="Zhu C" first="Chao" last="Zhu">Chao Zhu</name><affiliation wicri:level="1"><nlm:affiliation>d Department of Oral and Maxillofacial Surgery, Shandong Linyi People's Hospital , Linyi , China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>d Department of Oral and Maxillofacial Surgery, Shandong Linyi People's Hospital , Linyi </wicri:regionArea><wicri:noRegion>Linyi </wicri:noRegion></affiliation></author><author><name sortKey="Cai, Zhen" sort="Cai, Zhen" uniqKey="Cai Z" first="Zhen" last="Cai">Zhen Cai</name><affiliation wicri:level="1"><nlm:affiliation>d Department of Oral and Maxillofacial Surgery, Shandong Linyi People's Hospital , Linyi , China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>d Department of Oral and Maxillofacial Surgery, Shandong Linyi People's Hospital , Linyi </wicri:regionArea><wicri:noRegion>Linyi </wicri:noRegion></affiliation></author><author><name sortKey="He, Dongmei" sort="He, Dongmei" uniqKey="He D" first="Dongmei" last="He">Dongmei He</name><affiliation wicri:level="1"><nlm:affiliation>a Department of Oral and Maxillofacial Surgery, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai , China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>a Department of Oral and Maxillofacial Surgery, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai </wicri:regionArea><wicri:noRegion>Shanghai </wicri:noRegion></affiliation></author><author><name sortKey="Yang, Chi" sort="Yang, Chi" uniqKey="Yang C" first="Chi" last="Yang">Chi Yang</name><affiliation wicri:level="1"><nlm:affiliation>a Department of Oral and Maxillofacial Surgery, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai , China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>a Department of Oral and Maxillofacial Surgery, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai </wicri:regionArea><wicri:noRegion>Shanghai </wicri:noRegion></affiliation></author><author><name sortKey="Xu, Ling" sort="Xu, Ling" uniqKey="Xu L" first="Ling" last="Xu">Ling Xu</name><affiliation wicri:level="1"><nlm:affiliation>b Department of Prothodontics, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai , China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>b Department of Prothodontics, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai </wicri:regionArea><wicri:noRegion>Shanghai </wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>e Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology , Shanghai , China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>e Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology , Shanghai </wicri:regionArea><wicri:noRegion>Shanghai </wicri:noRegion></affiliation></author><author><name sortKey="Zheng, Jiawei" sort="Zheng, Jiawei" uniqKey="Zheng J" first="Jiawei" last="Zheng">Jiawei Zheng</name><affiliation wicri:level="1"><nlm:affiliation>a Department of Oral and Maxillofacial Surgery, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai , China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>a Department of Oral and Maxillofacial Surgery, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai </wicri:regionArea><wicri:noRegion>Shanghai </wicri:noRegion></affiliation></author></analytic><series><title level="j">Artificial cells, nanomedicine, and biotechnology</title><idno type="eISSN">2169-141X</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Bone Regeneration (MeSH)</term><term>Cell Differentiation (MeSH)</term><term>Cellular Microenvironment (MeSH)</term><term>Dogs (MeSH)</term><term>Inflammation (metabolism)</term><term>Inflammation (pathology)</term><term>Inflammation (physiopathology)</term><term>Male (MeSH)</term><term>Mesenchymal Stem Cell Transplantation (MeSH)</term><term>Mesenchymal Stem Cells (cytology)</term><term>Mesenchymal Stem Cells (metabolism)</term><term>Neovascularization, Physiologic (MeSH)</term><term>Osteogenesis (MeSH)</term><term>Signal Transduction (MeSH)</term><term>Toll-Like Receptor 2 (genetics)</term><term>Toll-Like Receptor 2 (metabolism)</term><term>Tooth Socket (diagnostic imaging)</term><term>Tooth Socket (metabolism)</term><term>Tooth Socket (pathology)</term><term>Tooth Socket (physiopathology)</term><term>X-Ray Microtomography (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Alvéole dentaire (anatomopathologie)</term><term>Alvéole dentaire (imagerie diagnostique)</term><term>Alvéole dentaire (métabolisme)</term><term>Alvéole dentaire (physiopathologie)</term><term>Animaux (MeSH)</term><term>Cellules souches mésenchymateuses (cytologie)</term><term>Cellules souches mésenchymateuses (métabolisme)</term><term>Chiens (MeSH)</term><term>Différenciation cellulaire (MeSH)</term><term>Inflammation (anatomopathologie)</term><term>Inflammation (métabolisme)</term><term>Inflammation (physiopathologie)</term><term>Microenvironnement cellulaire (MeSH)</term><term>Microtomographie aux rayons X (MeSH)</term><term>Mâle (MeSH)</term><term>Néovascularisation physiologique (MeSH)</term><term>Ostéogenèse (MeSH)</term><term>Récepteur de type Toll-2 (génétique)</term><term>Récepteur de type Toll-2 (métabolisme)</term><term>Régénération osseuse (MeSH)</term><term>Transduction du signal (MeSH)</term><term>Transplantation de cellules souches mésenchymateuses (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Toll-Like Receptor 2</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Alvéole dentaire</term><term>Inflammation</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Cellules souches mésenchymateuses</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Mesenchymal Stem Cells</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Tooth Socket</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Récepteur de type Toll-2</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Alvéole dentaire</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Inflammation</term><term>Mesenchymal Stem Cells</term><term>Toll-Like Receptor 2</term><term>Tooth Socket</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Alvéole dentaire</term><term>Cellules souches mésenchymateuses</term><term>Inflammation</term><term>Récepteur de type Toll-2</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Inflammation</term><term>Tooth Socket</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Alvéole dentaire</term><term>Inflammation</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Inflammation</term><term>Tooth Socket</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Bone Regeneration</term><term>Cell Differentiation</term><term>Cellular Microenvironment</term><term>Dogs</term><term>Male</term><term>Mesenchymal Stem Cell Transplantation</term><term>Neovascularization, Physiologic</term><term>Osteogenesis</term><term>Signal Transduction</term><term>X-Ray Microtomography</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Chiens</term><term>Différenciation cellulaire</term><term>Microenvironnement cellulaire</term><term>Microtomographie aux rayons X</term><term>Mâle</term><term>Néovascularisation physiologique</term><term>Ostéogenèse</term><term>Régénération osseuse</term><term>Transduction du signal</term><term>Transplantation de cellules souches mésenchymateuses</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The repair of periodontal bone tissue defects in patients with periodontitis is one of the major challenges for dentists. Stem cell-based bone regeneration has been considered as a promising strategy to restore the lost periodontal bone tissue. However, the local inflammatory environment of periodontal tissue affects stem cell-based periodontal bone regeneration. Toll-like receptor 2 (TLR2), a member of the TLR family, plays an important role in regulating immunoreaction. Previous studies have shown that the activation of TLR2 signaling pathway is involved in enhancing tissue vascularization and wound healing. However, the mechanisms underlying the therapeutic effects of TLR2 on regulating bone marrow stromal cells (BMSCs) mediated periodontal bone tissue regeneration still need to be further investigated. In this study, we tested the effect of TLR2 on regulating BMSCs mediated alveolar bone regeneration by establishing a TLR2 gene-modified canine BMSCs using a lentivirus. Activation of TLR2 significantly enhanced the expression of hypoxia-inducible factor-1α (HIF-1α) and bone morphogenetic protein 2 (BMP-2) and then upregulated the expression of their downstream osteogenic and angiogenic related gene in BMSCs. TLR2-BMSCs mediated bone regeneration in canine tooth extraction sockets under an inflammatory environment demonstrated that activation of the TLR2 signaling pathway significantly stimulated BMSCs meditated angiogenesis and osteogenesis.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31387403</PMID><DateCompleted><Year>2019</Year><Month>12</Month><Day>30</Day></DateCompleted><DateRevised><Year>2019</Year><Month>12</Month><Day>30</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">2169-141X</ISSN><JournalIssue CitedMedium="Internet"><Volume>47</Volume><Issue>1</Issue><PubDate><Year>2019</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Artificial cells, nanomedicine, and biotechnology</Title><ISOAbbreviation>Artif Cells Nanomed Biotechnol</ISOAbbreviation></Journal><ArticleTitle>The use of TLR2 modified BMSCs for enhanced bone regeneration in the inflammatory micro-environment.</ArticleTitle><Pagination><MedlinePgn>3329-3337</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1080/21691401.2019.1626867</ELocationID><Abstract><AbstractText>The repair of periodontal bone tissue defects in patients with periodontitis is one of the major challenges for dentists. Stem cell-based bone regeneration has been considered as a promising strategy to restore the lost periodontal bone tissue. However, the local inflammatory environment of periodontal tissue affects stem cell-based periodontal bone regeneration. Toll-like receptor 2 (TLR2), a member of the TLR family, plays an important role in regulating immunoreaction. Previous studies have shown that the activation of TLR2 signaling pathway is involved in enhancing tissue vascularization and wound healing. However, the mechanisms underlying the therapeutic effects of TLR2 on regulating bone marrow stromal cells (BMSCs) mediated periodontal bone tissue regeneration still need to be further investigated. In this study, we tested the effect of TLR2 on regulating BMSCs mediated alveolar bone regeneration by establishing a TLR2 gene-modified canine BMSCs using a lentivirus. Activation of TLR2 significantly enhanced the expression of hypoxia-inducible factor-1α (HIF-1α) and bone morphogenetic protein 2 (BMP-2) and then upregulated the expression of their downstream osteogenic and angiogenic related gene in BMSCs. TLR2-BMSCs mediated bone regeneration in canine tooth extraction sockets under an inflammatory environment demonstrated that activation of the TLR2 signaling pathway significantly stimulated BMSCs meditated angiogenesis and osteogenesis.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Qin</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>a Department of Oral and Maxillofacial Surgery, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gu</LastName><ForeName>Xiaoyu</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>b Department of Prothodontics, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dong</LastName><ForeName>Jiachen</ForeName><Initials>J</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-6476-9180</Identifier><AffiliationInfo><Affiliation>c Department of Periodontology, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhu</LastName><ForeName>Chao</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>d Department of Oral and Maxillofacial Surgery, Shandong Linyi People's Hospital , Linyi , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cai</LastName><ForeName>Zhen</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>d Department of Oral and Maxillofacial Surgery, Shandong Linyi People's Hospital , Linyi , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>He</LastName><ForeName>Dongmei</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>a Department of Oral and Maxillofacial Surgery, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Chi</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>a Department of Oral and Maxillofacial Surgery, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>Ling</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>b Department of Prothodontics, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai , China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>e Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology , Shanghai , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zheng</LastName><ForeName>Jiawei</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>a Department of Oral and Maxillofacial Surgery, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai , China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Artif Cells Nanomed Biotechnol</MedlineTA><NlmUniqueID>101594777</NlmUniqueID><ISSNLinking>2169-1401</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051195">Toll-Like Receptor 2</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001861" MajorTopicYN="Y">Bone Regeneration</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002454" MajorTopicYN="N">Cell Differentiation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D060833" MajorTopicYN="Y">Cellular Microenvironment</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004285" MajorTopicYN="N">Dogs</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007249" MajorTopicYN="N">Inflammation</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D045164" MajorTopicYN="N">Mesenchymal Stem Cell Transplantation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D059630" MajorTopicYN="N">Mesenchymal Stem Cells</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018919" MajorTopicYN="N">Neovascularization, Physiologic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010012" MajorTopicYN="N">Osteogenesis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051195" MajorTopicYN="N">Toll-Like Receptor 2</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020390" MajorTopicYN="N">Tooth Socket</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055114" MajorTopicYN="N">X-Ray Microtomography</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">BMSCs</Keyword><Keyword MajorTopicYN="N">TLR2</Keyword><Keyword MajorTopicYN="N">inflammatory</Keyword><Keyword MajorTopicYN="N">micro-environment</Keyword><Keyword MajorTopicYN="N">periodontal bone regeneration</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>8</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>8</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>12</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31387403</ArticleId><ArticleId IdType="doi">10.1080/21691401.2019.1626867</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Zhou, Qin" sort="Zhou, Qin" uniqKey="Zhou Q" first="Qin" last="Zhou">Qin Zhou</name></noRegion><name sortKey="Cai, Zhen" sort="Cai, Zhen" uniqKey="Cai Z" first="Zhen" last="Cai">Zhen Cai</name><name sortKey="Dong, Jiachen" sort="Dong, Jiachen" uniqKey="Dong J" first="Jiachen" last="Dong">Jiachen Dong</name><name sortKey="Gu, Xiaoyu" sort="Gu, Xiaoyu" uniqKey="Gu X" first="Xiaoyu" last="Gu">Xiaoyu Gu</name><name sortKey="He, Dongmei" sort="He, Dongmei" uniqKey="He D" first="Dongmei" last="He">Dongmei He</name><name sortKey="Xu, Ling" sort="Xu, Ling" uniqKey="Xu L" first="Ling" last="Xu">Ling Xu</name><name sortKey="Xu, Ling" sort="Xu, Ling" uniqKey="Xu L" first="Ling" last="Xu">Ling Xu</name><name sortKey="Yang, Chi" sort="Yang, Chi" uniqKey="Yang C" first="Chi" last="Yang">Chi Yang</name><name sortKey="Zheng, Jiawei" sort="Zheng, Jiawei" uniqKey="Zheng J" first="Jiawei" last="Zheng">Jiawei Zheng</name><name sortKey="Zhu, Chao" sort="Zhu, Chao" uniqKey="Zhu C" first="Chao" last="Zhu">Chao Zhu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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